Thermo Fisher Scientific SCN5A Polyclonal Antibody
SCN5A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인간 시료에 반응. 내부 영역 합성 펩타이드로 면역된 항체로 심근 전위 연구에 활용 가능. 연구용 전용.
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Applications
- Western Blot (WB): 1:300–1:2,000
- Immunohistochemistry (IHC): 1:300–1:2,000
- Miscellaneous PubMed (Misc): Not Applicable
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of human Sodium channel protein type 5 subunit alpha (SCN5A, Nav1.5) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCN5A.
Target Information
Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit found primarily in cardiac muscle. It is responsible for the initial upstroke of the action potential in an electrocardiogram.
Defects in Scn5a cause Long QT Syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Alternative splicing results in multiple transcript variants encoding different isoforms.
Voltage-gated sodium channels (VGSCs) mediate regenerative membrane depolarization and electrical conduction in nerves and muscles. Scn5a expression is also detected in lymphocytes, glia, and fibroblasts.
It mediates voltage-dependent sodium ion permeability of excitable membranes, forming sodium-selective channels responsive to voltage changes.
Functionally, Scn5a regulates the initial upstroke of the action potential, with channel inactivation influenced by intracellular calcium levels.
Diseases associated with SCN5A include Long QT Syndrome-3 and Brugada Syndrome 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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