Thermo Fisher Scientific SCN5A Polyclonal Antibody

Applications

• Western Blot (WB): 1:300–1:2,000
• Immunohistochemistry (IHC): 1:300–1:2,000
• Miscellaneous PubMed (Misc): Not Applicable

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Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCN5A.

Target Information

Scn5a is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit found primarily in cardiac muscle. It is responsible for the initial upstroke of the action potential in an electrocardiogram.
Defects in Scn5a cause Long QT Syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Alternative splicing results in multiple transcript variants encoding different isoforms.

Voltage-gated sodium channels (VGSCs) mediate regenerative membrane depolarization and electrical conduction in nerves and muscles. Scn5a expression is also detected in lymphocytes, glia, and fibroblasts.
It mediates voltage-dependent sodium ion permeability of excitable membranes, forming sodium-selective channels responsive to voltage changes.

Functionally, Scn5a regulates the initial upstroke of the action potential, with channel inactivation influenced by intracellular calcium levels.
Diseases associated with SCN5A include Long QT Syndrome-3 and Brugada Syndrome 1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.