Thermo Fisher Scientific Klotho Polyclonal Antibody
Klotho 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC에 적합합니다. 인간 KL 단백질(1-200 aa) 기반의 재조합 항원을 사용해 제작되었습니다. 뇌 및 신장 조직에서 높은 발현을 보이며, 노화 관련 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–200 of human KL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.32 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2804814 |
Product Specific Information
Immunogen sequence:
MPASAPPRRP RPPPPSLSLL LVLLGLGGRR LRAEPGDGAQ TWARFSRPPA PEAAGLFQGT FPDGFLWAVG SAAYQTEGGW QQHGKGASIW DTFTHHPLAP PGDSRNASLP LGAPSPLQPA TGDVASDSYN NVFRDTEALR ELGVTHYRFS ISWARVLPNG SAGVPNREGL RYYRRLLERL RELGVQPVVT LYHWDLPQRL
Positive samples: DU145, Mouse kidney, Mouse brain, Rat kidney
Cellular location: Cell membrane, Single-pass type I membrane protein
Target Information
KLOTHO is a systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, deficiency in KLOTHO expression leads to systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy, along with growth retardation, short lifespan, and infertility. Transgenic mice overexpressing KLOTHO exhibit extended lifespan by inhibiting insulin/IGF1 signaling. KLOTHO also regulates calcium/phosphorus homeostasis by inhibiting active vitamin D synthesis and is identified as a potential tumor suppressor.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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