Thermo Fisher Scientific TAK1 Polyclonal Antibody
TAK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity Chromatography로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 110–325 of human TAK1 (NP_663304.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.39 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804810 |
Product Specific Information
Immunogen sequence:
GSLYNVLHGA EPLPYYTAAH AMSWCLQCSQ GVAYLHSMQP KALIHRDLKP PNLLLVAGGT VLKICDFGTA CDIQTHMTNN KGSAAWMAPE VFEGSNYSEK CDVFSWGIIL WEVITRRKPF DEIGGPAFRI MWAVHNGTRP PLIKNLPKPI ESLMTRCWSK DPSQRPSMEE IVKIMTHLMR YFPGADEPLQ YPCQYSDEGQ SNSATSTGSF MDIAST
Positive Samples: Jurkat, K-562, Mouse liver, Mouse kidney
Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein
Target Information
TAK1 (MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to regulate JNK and p38 activation. It also mediates signaling through Wnt, BMP, activin, thyroid hormone, osmotic stress, endothelin, and ephrine pathways. TAK1 contributes to proper wound healing through regulation of PDGF-B and integrin expression and plays a central role in IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3 binding, polyubiquitination, and phosphorylation at Thr178, Thr184, Thr187, and Ser192. TAK1 also represses human telomerase reverse transcriptase, indicating a role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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