Thermo Fisher Scientific P-glycoprotein/p170/MDR1/CD243 Recombinant Rabbit Monoclonal Antibody (MDR1/8962R)
P-glycoprotein(MDR1/CD243) 검출용 재조합 토끼 단클론 항체로, 인간 시료에 반응합니다. IHC(Paraffin)에서 1–2 µg/mL로 사용 가능하며, 멤브레인 위치 단백질 검출에 적합합니다. Protein A/G 정제, 200 µg/mL 농도, PBS/BSA buffer에 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MDR1/8962R |
| Immunogen | Recombinant fragment (around aa500–700) of human ABCB1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: hPBL or Jurkat whole cell lysate, Human adrenal gland
- Cellular Location: Membrane
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily, which is involved in multidrug resistance. It functions as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to decreased drug accumulation in multidrug-resistant cells and resistance to anticancer drugs.
Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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