Thermo Fisher Scientific IL-17A Polyclonal Antibody
Mouse IL-17A에 특이적인 goat polyclonal antibody로, Western blot, Flow cytometry, Neutralization 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/trehalose buffer에 동결건조 상태로 제공. 높은 특이성과 낮은 교차반응률을 보임.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | View 1 publication |
| Flow Cytometry (Flow) | 2.5 µg per million cells | — |
| Neutralization (Neu) | 0.05–0.25 µg/mL | — |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse IL-17 (Thr22–Ala158) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607353 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human IL-17A and recombinant mouse IL-17F is observed.
- Less than 1% cross-reactivity with rmIL-17B, rmIL-17C, rmIL-17D, and rmIL-17E.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer (136 amino acids) belonging to the IL-17 family (IL-17A–F) and signals through IL-17R/CDw217.
It enhances ICAM-1 expression in fibroblasts and stimulates various cells to secrete IL-6, IL-8, G-CSF, and PGE2.
IL-17A regulates NF-kappa B and MAP kinase activities, stimulates IL-6 and COX-2 expression, and increases nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.