Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), PerCP-eFluor 710, eBioscience
CD185(CXCR5) 단클론 항체(MU5UBEE)는 인간 및 비인간 영장류의 CD185를 인식하며, PerCP-eFluor 710으로 표지된 유세포분석용 항체입니다. B세포 및 Tfh 세포 연구에 적합하며, 488nm 레이저로 여기되어 710nm에서 방출됩니다. 4°C 암소 보관, 동결 금지.
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- 46-9185-4x (2개 옵션)
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.06 µg)/test
- View 12 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rhesus monkey |
| Published Species | Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), PerCP-eFluor™ 710, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MU5UBEE |
| Immunogen | N-terminal extracellular domain of CXCR5 |
| Conjugate | PerCP-eFluor™ 710 |
| Excitation/Emission Max | 482/708 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573876 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 532, 700
- APC, Biotin
- Brilliant UV, Violet, Yellow series
- eFluor 450, FITC, PE, PE-Cy5, PE-Cy7, PE-eFluor 610
- Super Bright series
- NovaFluor Blue, Red, UV, Violet, Yellow series
- Request custom conjugation
Product Specific Information
The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185 (CXCR5, BLR1), a seven-transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma.
CD185 is expressed on B cells, CD4+ T cells (excluding Th1/Th2), and a subset of memory T cells. In tonsil, CD185+ cells coexpress CD45RO, CD69, and ICOS, supporting B cell help and antibody production.
This receptor is crucial for lymphocyte trafficking, particularly T cell migration into B cell follicles in response to CXCL13, making it a key marker for follicular helper T cells.
The antibody cross-reacts with Rhesus macaque.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated, tested on normal human peripheral blood cells
- Recommended Use: 5 µL (0.06 µg)/test in 100 µL final volume (10⁵–10⁸ cells/test)
- Fluorochrome: PerCP-eFluor® 710 (Ex 488 nm / Em 710 nm)
- Recommended Filter: 710/50 bandpass (695/40 acceptable alternative)
- Fixation: Samples can be stored up to 3 days at 4°C in the dark using
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CXCR5 (C-X-C Chemokine Receptor Type 5, CD185), also known as BLR1, is a G protein-coupled receptor for chemokine BLC. It is expressed in Burkitt’s lymphoma and lymphoid tissues such as lymph node follicles and spleen, playing a key role in B cell migration.
CXCR5 expression has been detected in:
- Human blood and salivary gland
- Animal lymphatic organs, bone marrow, brain, liver, lymph node, spleen, and tonsil
CXCR5 belongs to the GPCR family, characterized by seven transmembrane helices, and is involved in multiple signaling pathways and pharmacological targets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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