Thermo Fisher Scientific PHF17 Polyclonal Antibody
Rabbit polyclonal antibody specific to Human Jade1/PHF17 단백질. IHC(P) 및 ICC/IF에 사용 가능하며, PBS 기반 무보존제 액상 형태. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of Human Jade1/PHF17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788030 |
Product Specific Information
- This product is preservative-free.
- It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
- This antibody is specific for Human Jade1/PHF17.
Target Information
PHF17 (Jade1) is a scaffold subunit of some HBO1 complexes possessing histone H4 acetyltransferase activity. It plays a key role in directing KAT7/HBO1 specificity toward histone H4 acetylation (H4K5ac, H4K8ac, H4K12ac), regulating DNA replication initiation. It may also promote acetylation of nucleosomal histone H4 by KAT5 and promote apoptosis. PHF17 may act as a renal tumor suppressor and negatively regulate canonical Wnt signaling, cooperating with NPHP4 in this function. [UniProt]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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