Thermo Fisher Scientific BAMBI Monoclonal Antibody (OTI9G4), TrueMAB
BAMBI 단백질을 인식하는 Mouse monoclonal antibody (OTI9G4). Western blot에 최적화되어 있으며, Human 시료에 반응합니다. Lyophilized 형태로 제공되며, PBS와 trehalose buffer에 보관. 연구용으로 TGF-beta 신호 억제 관련 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9G4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 21–152 of human BAMBI produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane-spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development.
BAMBI transcription is regulated by beta-catenin, BMP, Smad3, and Smad4. Expression levels increase in colorectal and hepatocellular carcinomas compared to non-cancerous tissues.
It is highly expressed during odontogenesis and coexpressed with Bmp-4 during early Xenopus embryogenesis. BAMBI can also be detected in poorly metastatic human melanoma cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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