Thermo Fisher Scientific CDH2 Monoclonal Antibody (OTI6E5), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

Synthetic peptide sequence: RRMDERPIHAEPQYPVRS

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

N-cadherin is a 140 kDa transmembrane protein that mediates calcium-dependent intercellular adhesion. It plays a key role in morphogenetic movements during development and regulates cell surface adhesion through homotypic interactions.
Its function depends on association with the actin cytoskeleton via interactions between the C-terminal region and cytoplasmic catenin proteins. The stability of this complex is regulated by phosphorylation/dephosphorylation of beta-catenin.
N-cadherin comprises five extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail, functioning in gastrulation and left-right asymmetry establishment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.