Thermo Fisher Scientific CDH2 Monoclonal Antibody (OTI6E5), TrueMAB
인간 CDH2(N-cadherin)를 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 최적화됨. 합성 펩타이드 면역원 기반의 TrueMAB 형식. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 연구용으로 세포 부착 및 형태학적 연구에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E5 |
| Immunogen | Synthetic peptide sequence corresponding to residues of human CDH2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Synthetic peptide sequence: RRMDERPIHAEPQYPVRS
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
N-cadherin is a 140 kDa transmembrane protein that mediates calcium-dependent intercellular adhesion. It plays a key role in morphogenetic movements during development and regulates cell surface adhesion through homotypic interactions.
Its function depends on association with the actin cytoskeleton via interactions between the C-terminal region and cytoplasmic catenin proteins. The stability of this complex is regulated by phosphorylation/dephosphorylation of beta-catenin.
N-cadherin comprises five extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail, functioning in gastrulation and left-right asymmetry establishment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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