Thermo Fisher Scientific MPZ Recombinant Rabbit Monoclonal Antibody (3C4D1)
Recombinant rabbit monoclonal antibody specific for Myelin Protein Zero (MPZ). Validated for WB and ELISA. High specificity and sensitivity with minimal cross-reactivity. Supplied as liquid form, affinity purified, and suitable for neuroscience research.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:20,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3C4D1 |
| Immunogen | A synthetic peptide corresponding to amino acids 149–248 of human Myelin Protein Zero (MPZ) (NP_000521.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.18 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093892 |
Product Specific Information
Immunogen sequence:
KVPTRYGVVL GAVIGGVLGV VLLLLLLFYV VRYCWLRRQA ALQRRLSAME KGKLHKPGKD ASKRGRQTPV LYAMLDHSRS TKAVSEKKAK GLGESRKDKK
Target Information
Myelin Protein Zero (MPZ), also known as Zero, is a Type I integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath, ensuring stable synaptic transmission. MPZ constitutes approximately 50% of total protein in the peripheral myelin sheath, contributing to its structural integrity. It facilitates compact myelin wrapping via glycine zipper packing interface-dependent dimer and tetramer formation. Mutations, such as G134R, disrupt multimer formation and are linked to demyelinating neuropathies, including Charcot-Marie-Tooth disease. The cytoplasmic domain undergoes serine and tyrosine phosphorylation, particularly during peak nerve myelination. MPZ transcript levels are moderate in brain, abundant in thymus, and highest in white matter of the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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