Thermo Fisher Scientific MEMO1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MEMO1. Recombinant protein control fragment (Product #RP-96171). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MEMO1,uniProtId:Q9Y316-1,ncbiNodeId:9606,antigenRange:75-142,antigenLength:297,antigenImageFileName:PA5-60043_MEMO1_Q9Y316-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60043_MEMO1_Q9Y316-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2643871

Product Specific Information

Immunogen sequence: FILGPSHHVP LSRCALSSVD IYRTPLYDLR IDQKIYGELW KTGMFERMSL QTDEDEHSIE MHLPYTAK

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.