Thermo Fisher Scientific DTYMK Polyclonal Antibody
Human DTYMK 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 항체로, 0.7 mg/mL 농도. DNA 합성 경로 연구 및 항암제 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DTYMK. Recombinant protein control fragment (Product #RP-98923) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640819 |
Product Specific Information
Immunogen sequence:
DLVLFLQLQL ADAAKRGAFG HERYENGAFQ ERALRCFHQL MKDTTLNWKM VDASKSIEAV HEDIRVLSED AIRTAT
Antigen sequence identity:
Mouse – 68%, Rat – 71%
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis.
DTYMK is essential for DNA synthesis and serves as an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), a chemotherapeutic drug used for several solid tumors.
The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant (cdc8). DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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