Thermo Fisher Scientific Phospho-TSC2 (Thr938) Polyclonal Antibody
TSC2 단백질의 Thr938 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체. WB 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. 액상 형태로 1 mg/mL 농도, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Thr938. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817008 |
Product Specific Information
This antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Thr938.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) acts as a tumor suppressor and may function in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone. Phosphorylation on Ser939 and Thr1462 regulates its interaction with hamartin and is stimulated by growth factors via the PI3K/Akt pathway.
Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma. Alternative splicing results in three isoforms of TSC2.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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