Thermo Fisher Scientific Phospho-MAPKAPK2 (Thr221, Thr222) Polyclonal Antibody
MAPKAPK2의 Thr221/222 인산화 상태를 특이적으로 검출하는 다클론 항체로, WB 및 IHC(P) 실험에 적합함. 사람, 생쥐, 랫트 반응성이 있으며, 고순도 정제 및 안정적인 PBS/glycerol 저장 조건 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAPKAPK2 (Accession P49137), corresponding to amino acid residues around phosphorylated Thr221 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817005 |
Product Specific Information
This antibody detects endogenous levels of MAPKAPK2 only when phosphorylated at Thr221/222.
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is involved in multiple cellular processes such as stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation.
MAPKAPK2 encodes a member of the Ser/Thr protein kinase family and is regulated through direct phosphorylation by p38 MAP kinase.
Heat shock protein HSP27 is one of the substrates of this kinase in vivo.
Two transcript variants encoding different isoforms have been identified for MAPKAPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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