Thermo Fisher Scientific CXCR4, CXC Chemokine Receptor 4 Polyclonal Antibody
CXCR4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Human, Mouse, Rat에서 반응합니다. WB, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로 HIV 관련 및 세포 신호 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200 | View 2 publications |
| Not applicable (N/A) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence KGKRGGHSSVSTESESSSFHSS (residues 338–359 in human, mouse, and rat CXCR4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven transmembrane domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and has also been identified as a co-receptor for HIV-2 via envelope glycoprotein gp120, facilitating viral fusion. CXCR4 binds to the chemokine CXCL12/SDF-1, triggering intracellular calcium increase and MAPK pathway activation. Additionally, CXCR4 acts as a receptor for extracellular ubiquitin, influencing calcium and cAMP signaling. The receptor plays key roles in hematopoiesis, cardiac development, vascularization of the gastrointestinal tract, and neuronal survival in the CNS. It also mediates inflammatory responses through LPS binding and TNF secretion. Antibodies against CXCR4 can block HIV-1 and HIV-2 fusion and infection. The amino-terminal domain and second extracellular loop serve as HIV binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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