Thermo Fisher Scientific Phospho-CXC Chemokine Receptor 4 (Ser330) Polyclonal Antibody
Human 및 Mouse에서 CXCR4 Ser330 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태, 1 mg/mL 농도, 4°C 또는 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CXCR4 around the phosphorylation site of Ser330 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
CXCR4 (also known as Fusin, LESTR, HUMSTR) is a G-protein-coupled chemokine receptor with seven transmembrane domains. It functions as a co-receptor for X4 HIV-1 entry into CD4+ cells and has also been shown to mediate HIV-2 binding and fusion. CXCR4 serves as the receptor for the C-X-C chemokine CXCL12/SDF-1, triggering intracellular calcium increase and MAPK1/MAPK3 activation. It also acts as a receptor for extracellular ubiquitin, influencing calcium and cAMP levels.
CXCR4 is involved in hematopoiesis, cardiac ventricular septum formation, and gastrointestinal vascularization by regulating endothelial cell branching and remodeling. In the CNS, it contributes to hippocampal neuron survival and cerebellar development. CXCR4 can bind bacterial LPS, mediating inflammatory responses including TNF secretion by monocytes. Antibodies against CXCR4 can block HIV-1 and HIV-2 fusion and infection of human target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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