Thermo Fisher Scientific IL12RB2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:10,000
• Publications: View 1 publication

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji
• Predicted reactivity: Dog (80%), Pig (80%), Bovine (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. Coexpression of IL12RB2 and IL12RB1 leads to formation of high-affinity IL12 binding sites and reconstitution of IL12-dependent signaling. Expression is up-regulated by interferon gamma in Th1 cells and plays a role in Th1 differentiation. Up-regulation is associated with diseases such as Crohn’s disease and leprosy, contributing to inflammatory response and host defense.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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