Thermo Fisher Scientific CCR5 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

In Western blot applications, this antibody detects a band at approximately 40 kDa.
A suggested positive control is THP-1 cell lysate.

Target Information

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells.
Several G protein-coupled receptors, including CCR5, CXCR4, CCR3, CCR2b, and CCR8, have been identified as HIV coreceptors.
CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, mediating fusion and entry of human white blood cells.
CCR5 is required for infection by HIV-1, HIV-2, and SIV.
Beta-chemokines RANTES, MIP-alpha, and MIP-beta are ligands for CCR5 and prevent infection by M-tropic HIV-1.
CCR5 associates with the surface CD4-gp120 complex of HIV, leading to membrane fusion and virus entry into target cells.
The amino-terminal domain and extracellular loops of CCR5 serve as HIV binding sites.
CCR5 mRNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.

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