Thermo Fisher Scientific RBM28 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RBM28. Recombinant protein control fragment (Product #RP-92673). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RBM28,uniProtId:Q9NW13-1,ncbiNodeId:9606,antigenRange:373-488,antigenLength:759,antigenImageFileName:PA5-55371_RBM28_Q9NW13-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55371_RBM28_Q9NW13-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646381

Product Specific Information

Immunogen sequence: EHSKGCAFAQ FMTQEAAQKC LLAASPENEA GGLKLDGRQL KVDLAVTRDE AAKLQTTKVK KPTGTRNLYL AREGLIRAGT KAAEGVSAAD MAKRERFELL KHQKLKDQNI FVSRTR

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

Target Information

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.