Thermo Fisher Scientific ERRF Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ERRF. Recombinant protein control fragment (Product #RP-92440). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ERRF,uniProtId:Q8NEQ6-1,ncbiNodeId:9606,antigenRange:91-167,antigenLength:169,antigenImageFileName:PA5-55373_ERRF_Q8NEQ6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55373_ERRF_Q8NEQ6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2641120

Product Specific Information

Immunogen sequence: HLTRVTPMGG GCLAQARATL PLCRGSVASA SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW GTVKDSLKAL SSCVCGQ

Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 30%.

Target Information

The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.