Thermo Fisher Scientific RRAS Monoclonal Antibody (6A8)

Thermo Fisher Scientific RRAS Monoclonal Antibody (6A8)

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000
Publications: -

Product Specifications

Product Specific Information

A suggested positive control for this product is HeLa cells.

Target Information

The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms: a GDP-bound inactive form and a GTP-bound active form. The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein.

Small GTPases are monomeric G-proteins with molecular masses of 20–30 kDa. Ras is attached to the cell membrane by prenylation. Mutations in the Ras family of proto-oncogenes (H-Ras, N-Ras, K-Ras) are very common, found in 20–30% of all human tumors. K-Ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.