Thermo Fisher Scientific CD45RA Monoclonal Antibody (PTPRC, 818)

Thermo Fisher Scientific CD45RA Monoclonal Antibody (PTPRC, 818)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 min.

Target Information

CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes.
CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, regulating Src-family kinases.
Multiple isoforms exist due to alternative splicing; they differ in extracellular domains but share identical transmembrane and cytoplasmic domains.
CD45 isoforms vary in their membrane localization and expression depending on cell type and physiological state.
Besides immunoreceptor signaling, CD45 modulates integrin-mediated signal transduction and is involved in DNA fragmentation during apoptosis.
CD45 is expressed on human hematopoietic cells except mature red cells and is absent from differentiated non-hematopoietic tissues.
Dysfunction of CD45 is associated with severe combined immunodeficiency and Hepatitis C.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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