Thermo Fisher Scientific DRAM Polyclonal Antibody
DRAM 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P, PFA)에서 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 1 mg/mL 농도. DRAM 관련 자가포식 연구에 적합.
- 카탈로그번호
- PA520336
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–2.5 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide from near the amino terminus of human DRAM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153555 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20336 can be used with blocking peptide PEP-0456
Target Information
Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 occurs simultaneously with activation of proapoptotic genes such as PUMA and Bax, and that these pathways together promote a full cell death response.
By itself, DRAM cannot induce apoptosis, but its inactivation in certain cancers highlights its importance and suggests that autophagy may play a more significant role in cancer than previously thought.
At least two different isoforms of DRAM are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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