Thermo Fisher Scientific CD22 Monoclonal Antibody (IS7), PE
CD22 단백질을 인식하는 마우스 단클론 항체(IS7)로, PE 형광체가 결합되어 B세포 표면 분석에 적합합니다. 유세포분석(Flow Cytometry)에 사용되며, 인간 시료에서 반응합니다. 4°C에서 보관하며, 동결 금지.
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Applications
- Flow Cytometry (Flow): 20 µL/1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IS7 |
| Immunogen | Reh human cell line |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153351 |
Additional Formats
- Unconjugated (MA1-10141)
- APC (MA1-10143)
- FITC (MA1-10144)
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes. It is lost on plasma cells, peripheral blood T lymphocytes, granulocytes, and monocytes.
Target Information
CD22 (BL-CAM) is a type I integral membrane glycoprotein (130–140 kDa) expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 appears early in B-cell differentiation, similar to CD19, and is expressed on mature B cells (CD22⁺) but not plasma cells (CD22⁻). It is useful in phenotyping mature leukemias and is strongly expressed in hairy cell leukemia, diffuse large B-cell lymphoma, and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
CD22 preferentially binds to α2,6-linked sialic acid. Its sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand-induced tyrosine phosphorylation, CD22 is involved in regulation of B-cell receptor signaling. It can act as both a positive regulator via Src family tyrosine kinases and as an inhibitory receptor by recruiting cytoplasmic phosphatases that block signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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