Thermo Fisher Scientific ESR2 Monoclonal Antibody (OTI1E12), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Estrogen Receptor beta (ERβ, NR3A2) is a nuclear receptor protein (~55 kDa) with multiple isoforms (36–59 kDa).
ERβ was initially cloned from human testis and functions as a ligand-activated transcription factor within the steroid/thyroid hormone receptor superfamily. Upon estrogen binding, ERβ undergoes conformational change, dimerizes, and binds to estrogen response elements (EREs) in DNA to regulate gene transcription.

There are two main forms of estrogen receptors, ERα (ESR1) and ERβ (ESR2). ERβ binds estrogens with similar affinity to ERα and can inhibit ERα activity in reproductive tissues.
ERβ is widely expressed in various tissues and acts as a tumor suppressor, playing a role in conditions such as prostate cancer, medullary thyroid carcinoma, cardiovascular disease, and others.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.