Thermo Fisher Scientific TNFAIP8 Polyclonal Antibody
TNFAIP8 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 affinity chromatography 정제, 액상 형태로 안정적 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human TNFAIP8 (Accession O95379), corresponding to amino acid residues T41–F91 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853553 |
Product Specific Information
Antibody detects endogenous levels of total TFIP8.
Target Information
TNFalpha-IP 8 (tumor necrosis factor, alpha-induced protein 8), also known as NFkappa B-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFkappa B and TNF.
The induction of TNFalpha-IP 8 by TNF is dependent on NFkappa B activation. TNFalpha-IP 8 negatively mediates apoptosis and may play a role in tumor progression. It specifically inhibits caspase-8 activity, blocking BID cleavage and caspase-3 activation during TNF-mediated apoptosis.
TNFalpha-IP 8 is highly expressed in thymus, bone marrow, lymph node, spleen, thyroid, placenta, and various tumor tissues, as well as fetal lung, liver, and kidney. It exists in three isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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