Thermo Fisher Scientific ANP32C Polyclonal Antibody
Human ANP32C 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot, IHC, ICC/IF에 사용 가능. Affinity chromatography로 정제되었으며, PBS buffer(50% glycerol) 내 1 mg/mL 농도로 제공. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ANP32C (Accession O43423), corresponding to amino acid residues N125–Y175 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853551 |
Product Specific Information
Antibody detects endogenous levels of total ANP32C.
Target Information
ANP32C (acidic leucine-rich nuclear phosphoprotein 32 family, member C), also known as PP32R1 or tumorigenic protein pp32r1, is a 234 amino acid protein containing four leucine-rich repeats and belonging to the ANP32 family.
ANP32C shares 87.7% amino acid sequence identity with ANP32A, a tumor suppressor that inhibits various cancers such as prostate and breast cancers.
Unlike ANP32A, ANP32C is tumorigenic and expressed in activated stem cells (mobilized CD34+ and cord blood CD34+ cells) but not in resting bone marrow CD34+ cells.
It is also expressed in several neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines, but not in normal prostatic tissue, and may modulate the oncogenic potential of human prostate cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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