Thermo Fisher Scientific Phospho-TRKB (Tyr706) Polyclonal Antibody
Phospho-TRKB (Tyr706) 항체로 인간, 마우스, 랫트 시료에서 인산화된 TrkB 단백질 검출에 적합합니다. Western blot, IHC, ICC/IF에 사용 가능하며 고순도 액상 형태로 제공됩니다. 신경계 발달 및 시냅스 기능 연구에 유용합니다.
- 카탈로그번호
- PA5105012
- 판매단위
- pk
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-TRKB (Tyr706) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NTRK2 (Accession Q16620), corresponding to amino acid residues around phosphorylated Tyr706 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816485 |
Product Specific Information
This antibody detects endogenous levels of TrkB only when phosphorylated at Tyrosine 706.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family, which is essential for the development and maintenance of the mammalian nervous system. It serves as the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a tyrosine kinase gene related to TrkA and is expressed mainly in central and peripheral nervous system tissues. BDNF and NT-3 can induce rapid tyrosine phosphorylation of TrkB gp145, with BDNF showing a much stronger response. TrkB signaling leads to cell differentiation and involves MAPK pathway activation. Mutations in TrkB have been linked to obesity and mood disorders. Multiple isoforms are generated via alternate splicing.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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