Thermo Fisher Scientific DIS3 Polyclonal Antibody
DIS3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 시료에 반응하며 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었고 PBS 기반 용액 형태로 제공됩니다. RNA 처리 및 분해 관련 연구에 활용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DIS3 (Recombinant protein control fragment, Product #RP-106886) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665211 |
Product Specific Information
Immunogen sequence:
LSSNLCSLKCD VDRLAFSCIW EMNHNAEILK TKFTKSVINS KASLTYAEAQ LRIDSANMND DITTSLRGLN KLAKILKKRR IEKGALTLSS PEV
- Highest antigen sequence identity to orthologs: mouse 90%, rat 90%
Target Information
The exosome complex is involved in numerous cellular RNA processing and degradation events.
DIS3 (also known as exosome complex exonuclease RRP44) is a ribonuclease that participates in processing, turnover, and surveillance of various RNA species.
It localizes to both cytoplasm and nucleus, contains one PINc domain, and is widely expressed—most strongly in testis.
DIS3 is essential for processing 7S pre-RNA into a mature nuclear complex and for proper mitotic progression.
Abnormal expression may be associated with colon cancer, suggesting a role in tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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