ELK Biotechnology AAT1 rabbit pAb
AAT1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 생쥐, 랫드 시료에 반응. 미토콘드리아 및 세포질에 위치하며, 정자 형성과 관련된 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
AAT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA 310–390) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 66 kD |
| Gene ID (Human) | 89876 |
| Human Swiss-Prot No. | Q7Z4T9 |
| Cellular Localization | Mitochondrion, Cytoplasm, Cytoplasm (cytoskeleton, cilium axoneme), Localized in the neck of the sperm. [Isoform 7]: Cytoplasm. |
| Species Reactivity | Human; Rat; Mouse |
Background
Alternative products: Additional isoforms (AAT-1L and AAT-1S) may exist.
Function: Isoform 4 may play a role in spermatogenesis.
PTM: Isoform 4 is phosphorylated by PKA.
Subcellular location: Isoform 4 is found in the mitochondria and localized in the neck of the sperm.
Subunit: Interacts with AMY1 and AKAP1. Isoform 4 forms a complex with AMY1, AKAP1, and PRKAR2B. Isoform 3 does not interact with AMY1.
Tissue specificity: Isoform 1 is strongly expressed in the liver. Isoform 4 is widely expressed, particularly in spermatogenesis-related tissues including testis, cauda, and corpus epididymis epithelium. Isoform 4 is present in spermatid and mature sperm, and also expressed in Leydig cells. Isoform 3 is expressed in testis.
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