ELK Biotechnology ATS4 rabbit pAb

제품명

ATS4 rabbit pAb

제품 설명

ELK Biotechnology의 ATS4 rabbit pAb는 ADAMTS 단백질 패밀리의 인간 단백질로부터 유래한 합성 펩타이드를 면역원으로 사용하여 제작된 다클론 토끼 항체입니다. WB 및 ELISA 분석에 적합하며, 인간, 생쥐, 랫드 시료에서 반응합니다.

제품 사양

Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and may contribute to disease progression through degradation activity.