Thermo Fisher Scientific Apolipoprotein J Polyclonal Antibody
인체 Apolipoprotein J에 특이적인 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Apolipoprotein J (Product #RP-93716) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856027 |
Product Specific Information
Immunogen sequence:
SSIIDELFQD RFFTREPQDT YHYLPFSLPH RRPHFFFPKS RIVRSLMPFS PYEPLNFHAM FQPFLEMIHE AQQAMDIHFH SPAFQHPPTE FIREGDDDRT VCREIRHNS
Target Information
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. It inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP. Maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70. Does not refold proteins by itself.
Binding to cell surface receptors triggers internalization and degradation of the chaperone-client complex. Secreted isoform 1 protects cells against apoptosis and complement cytolysis.
Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes, promoting ubiquitination and proteasomal degradation of target proteins. Modulates NF-kappa-B activity.
Nuclear isoforms promote apoptosis, while mitochondrial isoforms suppress BAX-dependent cytochrome c release and inhibit apoptosis. Plays a role in regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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