Thermo Fisher Scientific Syntaxin 1 Recombinant Mouse Monoclonal Antibody (SP6)

Applications

Tested Dilution

Publications

Western Blot (WB)

3 µg/mL

-

Immunohistochemistry (PFA fixed) (IHC (PFA))

3 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Dog, Guinea pig, Hamster, Human, Pig, Rabbit, Rat

Host/Isotype

Mouse / IgG1, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SP6

Immunogen

Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Syntaxin 1,uniProtId:Q16623-1,ncbiNodeId:9606,antigenRange:1-288,antigenLength:288,antigenImageFileName:MA5-47883_Syntaxin_1_Q16623-1_House_mouse.svg,antigenImageFileNamePDP:MA5-47883_Syntaxin_1_Q16623-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3074327

Product Specific Information

Specificity: This antibody binds to native and denatured syntaxin.

Target Information

Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.