Thermo Fisher Scientific Bcl-rambo Polyclonal Antibody
Rabbit polyclonal antibody against human Bcl-rambo (Bcl2-L-13). Validated for Western blot. Targets mitochondrial and nuclear Bcl-rambo involved in apoptosis regulation. Supplied as liquid, 1 mg/mL, affinity purified, for research use only.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human Bcl2-L-13 aa 151–350/485 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092365 |
Product Specific Information
- Positive control: HeLa cell lysate, Jurkat cell lysate, Raji cell lysate
- Predicted band size: 53 kDa
- Subcellular Location: Mitochondrion membrane, Nucleus
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer. Members of the Bcl-2 family are critical regulators of apoptosis, characterized by conserved Bcl-2 homology (BH) domains.
Bcl-rambo is a novel, widely expressed member localized to mitochondria in mammalian cells. Its overexpression induces apoptosis, which can be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2.
Bcl-rambo shows homology to anti-apoptotic members but contains a unique 250 amino acid insertion preceding its C-terminal membrane anchor. This region can induce apoptosis more efficiently than the BH domains, suggesting Bcl-rambo’s role in additional pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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