Thermo Fisher Scientific Growth Hormone (Pituitary Marker) Monoclonal Antibody (GH/1450)

Thermo Fisher Scientific Growth Hormone (Pituitary Marker) Monoclonal Antibody (GH/1450)

Applications

• Immunohistochemistry (Paraffin) (IHC (P))
  Assay-dependent

• Immunohistochemistry (PFA fixed) (IHC (PFA))
  0.1–0.2 µg/mL

Product Specifications

Target Information

Human growth hormone (hGH) is a member of the somatotropin/prolactin family of hormones that play an important role in growth control.
The GH1 gene, along with four related genes, is located at the growth hormone locus on chromosome 17, sharing a high degree of sequence identity.
Alternative splicing results in five isoforms ranging from approximately 19 kDa to 24 kDa.

hGH is produced by somatotroph cells in the pituitary and acts via cytokine receptor subfamily membrane receptors.
Its major role is to stimulate body growth by inducing the liver and other tissues to secrete IGF-1.
It promotes differentiation and proliferation of myoblasts, amino acid uptake, and protein synthesis in muscle and other tissues.
Mutations or deletions in the gene lead to growth hormone deficiency and short stature.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.