Thermo Fisher Scientific SCAMP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Miscellaneous PubMed (Misc)

-

View 3 publications 3 publications

Product Specifications

Species Reactivity

Hamster, Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2184770

Product Specific Information

PA1-734 detects secretory carrier membrane protein 2 (SCAMP 2) from mouse testes and AtT20 cell extract as well as Chinese hamster ovary (CHO) cell extract.

PA1-734 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing SCAMP 2 from CHO cell extract.

PA1-734 immunizing peptide corresponds to amino acid residues 1-17 from human SCAMP 2. This sequence is completely conserved between human and mouse. PA1-734 immunizing peptide (Cat. # PEP-151) is available for use in neutralization and control experiments.

Target Information

Secretory carrier membrane proteins (SCAMPs) are proteins that are components of post-Golgi membranes. These proteins are implicated to function in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments that are involved in the recycling of cell surface receptors and endocytosis. In neurons, SCAMPs are associated with synaptic vesicles, secretion granules and transporter vesicles. SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1-3 contain cytoplasmic N-terminal regions with NPF repeats. NPF repeats are found to interact with EH domain proteins that function in budding of transport vesicles from the plasma membrane or the Golgi complex. SCAMPs 4 and 5 lack the N-terminal NPF repeats. SCAMPs 1-4 are all ubiquitously coexpressed while SCAMP 5 is only detectable in the brain. Studies show that SCAMP 5 is expressed late in development which is coincident with expansion of mature synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.