Thermo Fisher Scientific COX5B Polyclonal Antibody
Thermo Fisher Scientific의 COX5B Polyclonal Antibody는 인간 COX5B 단백질에 특이적인 토끼 다클론 항체입니다. Western blot, IHC, ICC/IF에 적합하며 고순도(>95%)로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human COX5B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719865 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
The cytochrome c oxidase (COX) family of proteins functions as the final electron donor in the respiratory chain, driving a proton gradient across the inner mitochondrial membrane and producing water. The mammalian COX apoenzyme is a dimer composed of 13 subunits, both mitochondrial and nuclear. COX5 is the heme A-containing chain of the oxidase family that converts one molecule of oxygen and four molecules of hydrogen into two molecules of water.
Two isoforms of COX5 exist: COX5a and COX5b. Under high oxygen conditions, COX5a (aerobic isoform) transcription increases, while under low oxygen conditions, COX5b (hypoxic isoform) transcription is upregulated to maximize COX apoenzyme turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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