Thermo Fisher Scientific UBASH3A Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UBASH3A (AAH28138.1, 1 a.a. approximately 451 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:UBASH3A,uniProtId:P57075-1,ncbiNodeId:9606,antigenRange:1-661,antigenLength:661,antigenImageFileName:H00053347-D01P_UBASH3A_P57075-1_Rabbit.svg,antigenImageFileNamePDP:H00053347-D01P_UBASH3A_P57075-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MAAGETQLYA KVSNKLKGRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA SLLADCSVKP CTKQLHLTLA HKFYPHHQRT LEQLARAIPL GHSCQWTAAL YSRDMRFVHY QTLRALFQYK PQNVDELTLS PGDYIFVDPT QQDEASEGWV IGISQRTGCR GFLPENYTDR ASESDTWVKH RMYTFSLATD LNSRKDGEAS SRCSGEFLPQ TARSLSSLQA LQATVARKSV LVVRHGERVD QIFGKAWLQQ CSTPDGNYYR PDLNFPCSLP RRSRGIKDFE NDPPLSSCGI FQSRIAGMFE DCLVGKVTIT ATLIMASRHP A

Target Information

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.