Thermo Fisher Scientific P53 proteinwt-p53 Polyclonal Antibody

Thermo Fisher Scientific P53 proteinwt-p53 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulation triggers transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and learning deficits due to increased levels affecting long-term potentiation (LTP). Normal cells express low levels of p53, whereas transformed cell lines show high expression, contributing to malignancy. Mutations in p53 often result in loss of DNA-binding ability and tumor suppressor function. Alterations of the TP53 gene occur both as somatic and germline mutations, including in Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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