Thermo Fisher Scientific CREB-1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth or neurotrophic factors. Activation of CREB depends on phosphorylation at serine 133, mediated by p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. Although CREB can bind DNA regardless of phosphorylation, only the phosphorylated form functions as a transcription factor. CREB interacts with CREB binding protein (CBP), a transcriptional coactivator, at the serine 133 region. CREB plays roles in circadian rhythm regulation, adipocyte differentiation, and learning and memory. In humans, the CREB gene is located on chromosome 2q. Dysregulation of CREB has been linked to Alzheimer’s disease, histiocytoma, and soft tissue melanoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.