Thermo Fisher Scientific MuERVL-Gag Polyclonal Antibody
마우스 시료에서 MuERVL-Gag 단백질을 검출하기 위한 Rabbit Polyclonal 항체. 합성 펩타이드 기반으로 제작되어 높은 특이성과 재현성을 제공. ICC/IF 실험에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within C-terminal residues of Gag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913311 |
Product Specific Information
- Positive Control: Mouse embryo.
Target Information
A large number of retrotransposons are expressed when the zygotic genome is first transcribed, including the endogenous retroviruses (ERVs), LINE-1 elements, and the non-autonomous SINE elements.
At the 2C stage, MuERV-L/MERVL retrovirus-like elements are transiently de-repressed and produce about 3% of the transcribed mRNAs. Following the 2C stage, MERVL-retroelement expression is silenced.
Recent studies discovered that this regulated pattern of MERVL expression overlapped with more than one hundred 2C-specific genes that have co-opted regulatory elements from these foreign retroviruses to initiate their transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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