Thermo Fisher Scientific HLA-DR Monoclonal Antibody (LN3), Super Bright 436, eBioscience
인간 HLA-DR 항원을 인식하는 LN3 단클론 항체로, Super Bright 436 형광체가 결합된 제품입니다. Flow cytometry에 최적화되어 있으며, 항원 제시 세포 표면 검출에 사용됩니다. Violet 레이저(405 nm)에서 효율적으로 여기되며, 높은 신호 대비를 제공합니다.
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Thermo Fisher Scientific HLA-DR Monoclonal Antibody (LN3), Super Bright 436, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 10 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), Super Bright 436, eBioscience |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LN3 |
| Conjugate | Super Bright 436 |
| Excitation / Emission Max | 413 / 431 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_2744821 |
Additional Formats Available
- Unconjugated
- Alexa Fluor 660
- Alexa Fluor 700
- Alexa Fluor Plus 488
- Alexa Fluor Plus 647
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV Series (395–805)
- Brilliant Violet Series (421–786)
- eFluor 450 / 506
- FITC
- NovaFluor Series (Blue, Violet, UV, Yellow)
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright Series (600–780)
- Request custom conjugation
Product Specific Information
The LN3 monoclonal antibody reacts with human MHC class II molecule HLA-DR.
HLA-DR is expressed on antigen-presenting cells (APCs) such as B cells, monocytes, macrophages, dendritic cells, and activated T cells.
It plays a key role in presenting peptides to CD4+ T lymphocytes.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested on human peripheral blood cells
- Recommended Usage: 5 µL (0.125 µg) per test (in 100 µL final volume)
- Excitation/Emission: 405 nm / 436 nm (Violet Laser)
- Filter Recommendation: 450/50 bandpass or equivalent
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Super Bright polymer dyes are sold under license from Becton, Dickinson and Company.
Target Information
HLA-DR is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB).
The alpha chain gene (DRA) contains 5 exons encoding the leader peptide, extracellular domains, transmembrane domain, and cytoplasmic tail.
The beta chain (DRB) contains polymorphisms defining peptide binding specificity.
Hundreds of DRB1 alleles exist, and typing is routinely performed for transplantation compatibility.
HLA-DR is expressed primarily on antigen-presenting cells such as:
- B lymphocytes
- Monocytes
- Macrophages
- Thymic epithelial cells
- Activated T lymphocytes
HLA and MHC antibodies are critical in Immunopeptidomics, aiding neoantigen identification via LC-MS/MS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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