Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI1H6), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in the regulation of T and B cell signaling through dual ITIM motifs. These motifs, upon kinase-mediated phosphorylation, provide docking sites for protein-tyrosine phosphatases. CD31 is ubiquitously expressed in the vascular system, mainly at intercellular junctions.
The N-terminal Ig-like domain mediates homophilic binding, crucial for cell-cell interaction. CD31 plays roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis, making it a key regulatory molecule in vascular biology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.