Thermo Fisher Scientific PECAM1 Monoclonal Antibody (OTI2C6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling through ITIM motifs that serve as docking sites for protein-tyrosine phosphatases after phosphorylation.
It is expressed throughout the vascular compartment, primarily at junctions between adjacent cells. The N-terminal Ig-like domain mediates homophilic binding, important for cell-cell interactions.

CD31 plays diverse roles in:

• Integrin-mediated cell adhesion
• Transendothelial migration
• Angiogenesis
• Apoptosis
• Negative regulation of immunoreceptor signaling
• Autoimmunity
• Macrophage phagocytosis
• IgE-mediated anaphylaxis
• Thrombosis

It is a key regulatory molecule in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.