Thermo Fisher Scientific NOR-1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human NOR-1 (NR4A3) protein. Validated for IHC(P) with 10 µg/mL dilution. Cross-reactive with multiple species. Supplied as liquid, 1 mg/mL in PBS with 0.1% sodium azide. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
Note: For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Pig, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from internal region of human NR4A3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551372 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Bovine, Dog, Elephant, Panda, Rabbit, Pig, Platypus (100%);
Marmoset, Mouse, Rat, Bat, Hamster, Opossum, Turkey, Chicken (94%).
Target Information
NOR-1 (NR4A3), a NR4 nerve growth factor-like receptor, influences neuronal development, T-cell apoptosis, and cancer progression. It binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 expression is rapidly but transiently induced by various stimuli. Downregulation of NOR-1 and other NGFI-B family members correlates with addiction-prone behavior in Lewis rats.
Three human isoforms are known: NOR-1, NOR-1β, and NOR-1 3′ variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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