Thermo Fisher Scientific IVNS1ABP Polyclonal Antibody
Rabbit polyclonal antibody against human IVNS1ABP protein. Validated for WB and IHC applications. Provides high sensitivity and specificity across multiple species. Suitable for research use in protein expression and pathway studies.
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- PA124418
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide region of human IVNS1ABP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_559698 |
Product Specific Information
- Recommended positive control: HepG2
- Predicted reactivity: Cow (100%), Dog (100%), Guinea Pig (100%), Horse (100%), Mouse (100%), Rabbit (100%), Rat (100%), Zebrafish (77%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
IVNS1ABP is a protein coding gene involved in various cellular processes, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization, and protein ubiquitination.
It stabilizes actin filaments by associating with F-actin through Kelch repeats, protecting cells from actin destabilization-induced death.
Acts as a modifier of the AHR pathway, increasing AHR availability for transcription activation.
Functions as a negative regulator of the BCR(KLHL20) E3 ubiquitin ligase complex, preventing ubiquitin-mediated degradation of tumor suppressors PML and DAPK1.
Also inhibits pre-mRNA splicing (in vitro) and, during microbial infection, participates in the alternative splicing of influenza A virus M1 mRNA via interaction with HNRNPK, facilitating M2 protein generation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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