Thermo Fisher Scientific P-Glycoprotein Polyclonal Antibody
P-glycoprotein을 인식하는 Rabbit Polyclonal Antibody로 인간 및 마우스 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제된 고순도 제품입니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific P-Glycoprotein Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide of human P-glycoprotein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803838 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
ABC proteins transport various molecules across extra- and intra-cellular membranes.
ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance.
The protein encoded by this gene acts as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity.
It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates resistance to anticancer drugs.
Additionally, this protein functions as a transporter in the blood-brain barrier.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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