Thermo Fisher Scientific ITFG2 Monoclonal Antibody (OTI3G4), TrueMAB
ITFG2 단백질을 인식하는 마우스 단클론 항체로, Western Blot에 최적화되어 있습니다. HEK293T 세포에서 발현된 full-length human ITFG2 단백질로 면역화되었습니다. 친화 크로마토그래피로 정제되었으며, 동결 건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G4 |
| Immunogen | Full-length human recombinant ITFG2 protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ITFG2 is a component of the KICSTOR complex, functioning in the amino acid-sensing branch of the TORC1 signaling pathway. It recruits the GATOR1 complex to lysosomal membranes, enabling interaction with GATOR2 and RAG GTPases. ITFG2 acts upstream of RAG GTPases to negatively regulate mTORC1 signaling in the absence of amino acids. Without the KICSTOR complex, mTORC1 remains constitutively active at the lysosome. The KICSTOR complex may also play a role in glucose-mediated regulation of mTORC1.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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