Thermo Fisher Scientific Tubulin beta 3/TUBB3 (Neuronal and Stem Cell Marker) Recombinant Rabbit Monoclonal Antibody (TUBB3/7089R)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Stability: Antibody is stable for 24 months.
• Positive Control: Human brain or testis.
• Cellular Localization: Cytoplasm.
• Specificity Comments:
  This gene encodes a class III member of the beta tubulin protein family. Beta tubulins form microtubules through heterodimerization with alpha tubulins. TUBB3 is primarily expressed in neurons and is involved in neurogenesis, axon guidance, and maintenance. Mutations in this gene are associated with congenital fibrosis of the extraocular muscles type 3. In adults, TUBB3 serves as a neuronal marker essential for neuronal cell proliferation and differentiation.

Target Information

The betaIII-tubulin isoform is predominantly expressed in neuronal cells and serves as an early marker of neuronal differentiation. It is a specific probe for neurons and neuron-derived tumors. Although most abundant in neuronal cells, betaIII-tubulin is also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.