Thermo Fisher Scientific Catenin beta Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive control: Human lung adenocarcinoma
• Cellular location: Cytoplasm, Nucleus

Target Information

Beta-catenin is an adherens junction (AJ) protein originally identified as a component of cell-cell adhesion structures. AJs are essential for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links it to alpha-catenin, which mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton.

Studies show that Beta-catenin also binds to cytoskeletal complexes containing the adenomatous polyposis coli protein and microtubules, and interacts with signaling pathways including tyrosine kinases, phosphatases, and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes, and signaling pathways may regulate morphogenesis.

Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheaths. A pathological role has been identified in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and tumor development. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors that stimulate transcription of target genes such as cyclin D and c-myc, promoting cell proliferation. This regulatory influence is central to its role in tumorigenesis, particularly in solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.